Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators

[Image: see text] Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in multiple tissue types. Abnormal LPA expression can lead to the progression of diseases such as ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Clark, Jennifer M., Salgado-Polo, Fernando, Macdonald, Simon J. F., Barrett, Tim N., Perrakis, Anastassis, Jamieson, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059126/
https://www.ncbi.nlm.nih.gov/pubmed/35440138
http://dx.doi.org/10.1021/acs.jmedchem.2c00368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059126/
https://www.ncbi.nlm.nih.gov/pubmed/35440138
http://dx.doi.org/10.1021/acs.jmedchem.2c00368

Ejemplares similares