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Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence

[Image: see text] In this work, we investigated the influence of stabilizing (N,N,N-trimethylglycine) and destabilizing (urea) osmolytes on the hydration spheres of biomacromolecules in folded forms (trpzip-1 peptide and hen egg white lysozyme—hewl) and unfolded protein models (glycine—GLY and N-met...

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Detalles Bibliográficos
Autores principales: Stasiulewicz, Marcin, Panuszko, Aneta, Bruździak, Piotr, Stangret, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059127/
https://www.ncbi.nlm.nih.gov/pubmed/35441516
http://dx.doi.org/10.1021/acs.jpcb.2c00281