Cargando…

The potential role of the 5,6-dihydropyridin-2(1H)-one unit of piperlongumine on the anticancer activity

Piperlongumine (PL), a potent anticancer agent from the plant long pepper (Piper longum), contains the 5,6-dihydropyridin-2(1H)-one heterocyclic scaffold and cinnamoyl unit. In this paper, we synthesized a series of PL analogs and evaluated their cytotoxicity against cancer cells for the sake of exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mu, Wen-Wen, Li, Peng-Xiao, Liu, Yue, Yang, Jie, Liu, Guo-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059148/ https://www.ncbi.nlm.nih.gov/pubmed/35516728 http://dx.doi.org/10.1039/d0ra08778e

Ejemplares similares

Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation
por: Sun, Ai-Ling, et al.
Publicado: (2021)

Synthesis of 5,6-Dihydropyridin-2(1H)-ones, 1,5,6,8,8a-Hexa-hydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-Hexahydro-quinolin-2(1H)-ones by Intramolecular Wittig Reaction
por: Fisyuk, Alexander S., et al.
Publicado: (2002)

Data for the synthesis and characterisation of 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines as important intermediates for synthesis of amphiphilic 1,4-dihydropyridines
por: Rucins, Martins, et al.
Publicado: (2020)

On the Inhibition Mechanism of Glutathione Transferase P1 by Piperlongumine. Insight From Theory
por: Prejanò, Mario, et al.
Publicado: (2018)

5,6-Dimethyl-4-phenyl-2H-pyran-2-one
por: Xu, Hai-Yun, et al.
Publicado: (2012)

Preformulation Studies on Piperlongumine
por: Aodah, Alhassan, et al.
Publicado: (2016)

Intramolecular hydrogen bonds in 1,4-dihydropyridine derivatives
por: Petrova, M., et al.
Publicado: (2018)

Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis
por: Parsons, Leo W. T., et al.
Publicado: (2023)

An umpolung approach to the hydroboration of pyridines: a novel and efficient synthesis of N-H 1,4-dihydropyridines
por: Yang, Huan, et al.
Publicado: (2019)

The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition
por: Chen, Xiu-Yu, et al.
Publicado: (2023)

Metabolic profile and safety of piperlongumine
por: de Lima Moreira, Fernanda, et al.
Publicado: (2016)

Study on the coordination of cyclopentanocucurbit[5,6]uril with Fe(3+), Co(2+) and Ni(2+) ions
por: Zheng, Jun, et al.
Publicado: (2022)

The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
por: Pan, You-lu, et al.
Publicado: (2022)

Synthesis and Anticancer Activity of Mitotic-Specific 3,4-Dihydropyridine-2(1H)-thiones
por: Perużyńska, Magdalena, et al.
Publicado: (2021)

Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
por: Huang, Jia-Rong, et al.
Publicado: (2020)

1,4-Dihydropyridine: synthetic advances, medicinal and insecticidal properties
por: A., Parthiban, et al.
Publicado: (2022)

Retraction: One-pot synthesis of Hantzsch dihydropyridines using a highly efficient and stable PdRuNi@GO catalyst
por: Fisher, Laura
Publicado: (2021)

Divergent synthesis of dual 1,4-dihydropyridines with different substituted patterns from enaminones and aldehydes through domino reactions
por: Liu, Fu-Jun, et al.
Publicado: (2018)

A one-pot synthesis of N(2),6-diaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines and systematic evaluation of their ability to host ethanol in crystals
por: Junaid, Ahmad, et al.
Publicado: (2019)

Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters
por: Gavin, Joshua T., et al.
Publicado: (2018)

Identification of Piperlongumine as Potent Inhibitor of Necroptosis
por: He, Xiaoyan, et al.
Publicado: (2023)

Survivin Promotes Piperlongumine Resistance in Ovarian Cancer
por: Nan, Xing-Wei, et al.
Publicado: (2019)

AlCl(3)@ZnO nanostructured material: an efficient green catalyst for the one-pot solvent-free synthesis of 1,4-dihydropyridines
por: Shinde, Santosh T., et al.
Publicado: (2023)

Convenient and efficient synthesis of novel 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones derived from 2-bromo-(2/3-substitutedphenyl)-1H-indene-1,3(2H)-diones
por: Mor, Satbir, et al.
Publicado: (2019)

Piperlongumine Is an NLRP3 Inhibitor With Anti-inflammatory Activity
por: Shi, Jie, et al.
Publicado: (2022)

Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridines
por: Bissonnette, Noah B., et al.
Publicado: (2019)

5,6-Dimethyl-1H-benzimidazol-3-ium nitrate
por: Liu, Bao-Cheng, et al.
Publicado: (2013)

Expedient synthesis of eumelanin-inspired 5,6-dihydroxyindole-2-carboxylate ethyl ester derivatives
por: Aebly, Andrew H., et al.
Publicado: (2018)

Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
por: Kung, Fang-Ping, et al.
Publicado: (2021)

Correction: AlCl(3)@ZnO nanostructured material: an efficient green catalyst for the one-pot solvent-free synthesis of 1,4-dihydropyridines
por: Shinde, Santosh T., et al.
Publicado: (2023)

Metal-Free Direct C–H Functionalization of Quinoxalin-2(1H)-Ones to Produce 3-Vinylated Quinoxalin-2(1H)-Ones in the Presence of Alkenes
por: Ding, Rongcai, et al.
Publicado: (2021)

Axially chiral 1,4-dihydropyridine derivatives: aggregation-induced emission in exciplexes and application as viscosity probes
por: Yang, Zeren, et al.
Publicado: (2019)

Recent developments in the nanomaterial-catalyzed green synthesis of structurally diverse 1,4-dihydropyridines
por: Mathur, Ritu, et al.
Publicado: (2021)

Recent Progresses in the Multicomponent Synthesis of Dihydropyridines by Applying Sustainable Catalysts Under Green Conditions
por: Sonali Anantha, Immandhi Sai, et al.
Publicado: (2021)

Correction: Expedient synthesis of eumelanin-inspired 5,6-dihydroxyindole-2-carboxylate ethyl ester derivatives
por: Aebly, Andrew H., et al.
Publicado: (2019)

Piperlongumine-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane
por: Bissinger, Rosi, et al.
Publicado: (2014)

Piperlongumine promotes death of retinoblastoma cancer cells
por: Allaman-Pillet, Nathalie, et al.
Publicado: (2021)

The promising potential of piperlongumine as an emerging therapeutics for cancer
por: Parama, Dey, et al.
Publicado: (2021)

Poly[[diaqua(μ(4)-1H-benzimidazole-5,6-dicarboxylato)strontium] monohydrate]
por: Song, Wen-Dong, et al.
Publicado: (2009)

Visible-Light-Induced C–C Coupling Reaction to Synthesize Bipyridine From 3-Cyano-1,4-Dihydropyridines
por: Chen, Shijun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dumov2kroqlug76b2u4o73e4ia