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Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells
Understanding metabolic pathways that regulate Th17 development is important to broaden therapeutic options for Th17-mediated autoimmunity. Here, we report a pivotal role of mitochondrial oxidative phosphorylation (OXPHOS) for lineage specification toward pathogenic Th17 differentiation. Th17 cells...
Autores principales: | Shin, Boyoung, Benavides, Gloria A., Geng, Jianlin, Koralov, Sergei B., Hu, Hui, Darley-Usmar, Victor M., Harrington, Laurie E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059282/ https://www.ncbi.nlm.nih.gov/pubmed/32049019 http://dx.doi.org/10.1016/j.celrep.2020.01.022 |
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