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Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury

Damage to long axons in white matter tracts is a major pathology in closed head traumatic brain injury (TBI). Acute TBI treatments are needed that protect against axon damage and promote recovery of axon function to prevent long term symptoms and neurodegeneration. Our prior characterization of axon...

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Detalles Bibliográficos
Autores principales: Radomski, Kryslaine L., Zi, Xiaomei, Lischka, Fritz W., Noble, Mark D., Galdzicki, Zygmunt, Armstrong, Regina C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059462/
https://www.ncbi.nlm.nih.gov/pubmed/35501931
http://dx.doi.org/10.1186/s40478-022-01366-z