Role of the disulfide bond on the structure and activity of μ-conotoxin PIIIA in the inhibition of Na(V)1.4

μ-Conotoxin PIIIA, a peptide toxin isolated from Conus purpurascens, blocks the skeletal muscle voltage-gated sodium channel Na(V)1.4 with significant potency. PIIIA has three disulfide bonds, which contribute largely to its highly constrained and stable structure. In this study, a combination of ex...

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Detalles Bibliográficos
Autores principales: Xu, Xiaoxiao, Xu, Qingliang, Chen, Fangling, Shi, Juan, Liu, Yuntian, Chu, Yanyan, Wan, Shengbiao, Jiang, Tao, Yu, Rilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059534/
https://www.ncbi.nlm.nih.gov/pubmed/35517619
http://dx.doi.org/10.1039/c8ra06103c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059534/
https://www.ncbi.nlm.nih.gov/pubmed/35517619
http://dx.doi.org/10.1039/c8ra06103c

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