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Total synthesis of diazaquinomycins H and J using double Knorr cyclization in the presence of triisopropylsilane
The first total synthesis of diazaquinomycins H (1) and J (2), which are promising anti-tuberculosis natural product leads, has been achieved via selective amidation of diamine 6 with Meldrum's acid derivatives, subsequent EDC coupling with 3-oxobutanoic acid, followed by double Knorr cyclizati...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society of Chemistry
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059765/ https://www.ncbi.nlm.nih.gov/pubmed/35516148 http://dx.doi.org/10.1039/c8ra09792e |