Efficient synthesis of Ibrutinib chiral intermediate in high space-time yield by recombinant E. coli co-expressing alcohol dehydrogenase and glucose dehydrogenase

The production of (S)-N-boc-3-hydroxy piperidine (NBHP) via asymmetric bioreduction of 1-boc-3-piperidinone with reductase is impeded by the need for expensive coenzymes NAD(P)H. In order to regenerate the coenzyme in situ, the gene of alcohol dehydrogenase from Thermoanaerobacter brockii and glucos...

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Detalles Bibliográficos
Autores principales: Chen, Yitong, Ma, Baodi, Cao, Songshuang, Wu, Xiaomei, Xu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059822/
https://www.ncbi.nlm.nih.gov/pubmed/35516114
http://dx.doi.org/10.1039/c8ra08100j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059822/
https://www.ncbi.nlm.nih.gov/pubmed/35516114
http://dx.doi.org/10.1039/c8ra08100j

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