Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand...

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Autores principales: Zhang, Chuan-Tao, Zhu, Rui, Wang, Zheng, Ma, Bing, Zajac, Adrian, Smiglak, Marcin, Xia, Chun-Nian, Castle, Steven L., Wang, Wen-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059842/
https://www.ncbi.nlm.nih.gov/pubmed/35516141
http://dx.doi.org/10.1039/c8ra07447j
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author Zhang, Chuan-Tao
Zhu, Rui
Wang, Zheng
Ma, Bing
Zajac, Adrian
Smiglak, Marcin
Xia, Chun-Nian
Castle, Steven L.
Wang, Wen-Long
author_facet Zhang, Chuan-Tao
Zhu, Rui
Wang, Zheng
Ma, Bing
Zajac, Adrian
Smiglak, Marcin
Xia, Chun-Nian
Castle, Steven L.
Wang, Wen-Long
author_sort Zhang, Chuan-Tao
collection PubMed
description An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour(−1).
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spelling pubmed-90598422022-05-04 Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran Zhang, Chuan-Tao Zhu, Rui Wang, Zheng Ma, Bing Zajac, Adrian Smiglak, Marcin Xia, Chun-Nian Castle, Steven L. Wang, Wen-Long RSC Adv Chemistry An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour(−1). The Royal Society of Chemistry 2019-01-17 /pmc/articles/PMC9059842/ /pubmed/35516141 http://dx.doi.org/10.1039/c8ra07447j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Chuan-Tao
Zhu, Rui
Wang, Zheng
Ma, Bing
Zajac, Adrian
Smiglak, Marcin
Xia, Chun-Nian
Castle, Steven L.
Wang, Wen-Long
Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran
title Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran
title_full Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran
title_fullStr Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran
title_full_unstemmed Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran
title_short Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran
title_sort continuous flow synthesis of diaryl ketones by coupling of aryl grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059842/
https://www.ncbi.nlm.nih.gov/pubmed/35516141
http://dx.doi.org/10.1039/c8ra07447j
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