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Do soft anions promote protein denaturation through binding interactions? A case study using ribonuclease A

It has long been known that large soft anions like bromide, iodide and thiocyanate are protein denaturing agents, but their mechanism of action is still unclear. In this work we have investigated the protein denaturing properties of these anions using Ribonuclease A (RNase A) as a model protein syst...

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Detalles Bibliográficos
Autores principales: Francisco, Olga A., Clark, Courtney J., Glor, Hayden M., Khajehpour, Mazdak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060304/
https://www.ncbi.nlm.nih.gov/pubmed/35518962
http://dx.doi.org/10.1039/c8ra10303h