A molecular switch controls the impact of cholesterol on a Kir channel

Cholesterol decreases the activity of the majority of ion channels while increasing the activity of only a few, yet it remains unclear how. Here, we used the inwardly rectifying potassium channel Kir3.4, which is up-regulated by cholesterol, as a tool to address this question. Employing mutagenesis...

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Detalles Bibliográficos
Autores principales: Corradi, Valentina, Bukiya, Anna N., Miranda, Williams E., Cui, Meng, Plant, Leigh D., Logothetis, Diomedes E., Tieleman, D. Peter, Noskov, Sergei Y., Rosenhouse-Dantsker, Avia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060494/
https://www.ncbi.nlm.nih.gov/pubmed/35333652
http://dx.doi.org/10.1073/pnas.2109431119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060494/
https://www.ncbi.nlm.nih.gov/pubmed/35333652
http://dx.doi.org/10.1073/pnas.2109431119

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