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KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3

KCNQ2 and KCNQ3 channels are associated with multiple neurodevelopmental disorders and are also therapeutic targets for neurological and neuropsychiatric diseases. For more than two decades, it has been thought that most KCNQ channels in the brain are either KCNQ2/3 or KCNQ3/5 heteromers. Here, we i...

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Detalles Bibliográficos
Autores principales: Soh, Heun, Springer, Kristen, Doci, Klarita, Balsbaugh, Jeremy L., Tzingounis, Anastasios V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060518/
https://www.ncbi.nlm.nih.gov/pubmed/35320039
http://dx.doi.org/10.1073/pnas.2117640119