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Interspecies differences in stability kinetics and plasma esterases involved in hydrolytic activation of curcumin diethyl disuccinate, a prodrug of curcumin

The investigation of in vitro plasma metabolism of ester prodrugs is an important part of in vitro ADME assays during preclinical drug development. Here, we show that the in vitro metabolism including plasma stability and metabolizing enzymes of curcumin diethyl disuccinate (CDD), an ester prodrug o...

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Detalles Bibliográficos
Autores principales: Ratnatilaka Na Bhuket, Pahweenvaj, Jithavech, Ponsiree, Ongpipattanakul, Boonsri, Rojsitthisak, Pornchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060607/
https://www.ncbi.nlm.nih.gov/pubmed/35520191
http://dx.doi.org/10.1039/c8ra08594c