A simple liquid chromatography-tandem mass spectrometry method to accurately determine the novel third-generation EGFR-TKI naquotinib with its applicability to metabolic stability assessment

Naquotinib (ASP8273, NQT) is a novel third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs). NQT was found to be more effective than osimertinib against the EGFR L858R plus T790M mutation (L858R+T790M). A rapid resolution liquid chromatography (RRLC)-tandem mass spec...

Descripción completa

Detalles Bibliográficos
Autores principales: Alrabiah, Haitham, Kadi, Adnan A., Attwa, Mohamed W., Abdelhameed, Ali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060617/
https://www.ncbi.nlm.nih.gov/pubmed/35514667
http://dx.doi.org/10.1039/c8ra09812c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060617/
https://www.ncbi.nlm.nih.gov/pubmed/35514667
http://dx.doi.org/10.1039/c8ra09812c

Ejemplares similares