Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening

The general control nonrepressed protein 5 (GCN5) is an important target for drug design and drug discovery largely owing to its pathogenic role in malignancies. Chemical probes that target GCN5 have been developed in recent decades, but their potencies are still unsatisfactory. In this study, throu...

Descripción completa

Detalles Bibliográficos
Autores principales: Tao, Hongru, Wang, Jun, Lu, Wenchao, Zhang, Rukang, Xie, Yiqian, Liu, Yu-Chih, Liu, Rongfeng, Yue, Liyan, Chen, Kaixian, Jiang, Hualiang, Zhang, Yuanyuan, Xu, Xiaohui, Luo, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060691/
https://www.ncbi.nlm.nih.gov/pubmed/35514635
http://dx.doi.org/10.1039/c8ra10074h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060691/
https://www.ncbi.nlm.nih.gov/pubmed/35514635
http://dx.doi.org/10.1039/c8ra10074h

Ejemplares similares