Cisplatin, glutathione and the third wheel: a copper-(1,10-phenanthroline) complex modulates cisplatin–GSH interactions from antagonism to synergism in cancer cells resistant to cisplatin

The antagonistic effect of glutathione (GSH) against the cytotoxicity of cisplatin was observed in both wild type and cisplatin-resistant human leukaemia and ovarian carcinoma cell lines. The simultaneous presence of the cytotoxic copper complex [Cu(phen)(2)(OH(2))](ClO(4))(2) (C0) restored the sens...

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Detalles Bibliográficos
Autores principales: Vascellari, Sarah, Valletta, Elisa, Perra, Daniela, Pinna, Elisabetta, Serra, Alessandra, Isaia, Francesco, Pani, Alessandra, Pivetta, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060805/
https://www.ncbi.nlm.nih.gov/pubmed/35515894
http://dx.doi.org/10.1039/c8ra09652j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060805/
https://www.ncbi.nlm.nih.gov/pubmed/35515894
http://dx.doi.org/10.1039/c8ra09652j

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