Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO(−)) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO(−) in APAP-induced liver injury. This new probe will be a us...

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Autores principales: Ma, Ying, Tian, Haigang, Jin, Zhengyu, Li, Xiaoyong, Li, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061049/
https://www.ncbi.nlm.nih.gov/pubmed/35518452
http://dx.doi.org/10.1039/c8ra10053e
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author Ma, Ying
Tian, Haigang
Jin, Zhengyu
Li, Xiaoyong
Li, Yiping
author_facet Ma, Ying
Tian, Haigang
Jin, Zhengyu
Li, Xiaoyong
Li, Yiping
author_sort Ma, Ying
collection PubMed
description A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO(−)) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO(−) in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO(−)in vivo.
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spelling pubmed-90610492022-05-04 Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe Ma, Ying Tian, Haigang Jin, Zhengyu Li, Xiaoyong Li, Yiping RSC Adv Chemistry A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO(−)) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO(−) in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO(−)in vivo. The Royal Society of Chemistry 2019-02-25 /pmc/articles/PMC9061049/ /pubmed/35518452 http://dx.doi.org/10.1039/c8ra10053e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ma, Ying
Tian, Haigang
Jin, Zhengyu
Li, Xiaoyong
Li, Yiping
Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
title Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
title_full Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
title_fullStr Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
title_full_unstemmed Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
title_short Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
title_sort observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061049/
https://www.ncbi.nlm.nih.gov/pubmed/35518452
http://dx.doi.org/10.1039/c8ra10053e
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