Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI

Pseudouridine, one major RNA modification, is catabolized into uracil and ribose-5′-phosphate by two sequential enzymatic reactions. In the first step, pseudouridine kinase (PUKI) phosphorylates pseudouridine to pseudouridine 5′-monophosphate. High-fidelity catalysis of pseudouridine by PUKI prevent...

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Detalles Bibliográficos
Autores principales: Kim, Sang-Hoon, Kim, Minjeong, Park, Daechan, Byun, Sujeong, Rhee, Sangkee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061257/
https://www.ncbi.nlm.nih.gov/pubmed/35346685
http://dx.doi.org/10.1016/j.jbc.2022.101869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061257/
https://www.ncbi.nlm.nih.gov/pubmed/35346685
http://dx.doi.org/10.1016/j.jbc.2022.101869

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