Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin

Chaperones, as modulators of protein conformational states, are key cellular actors to prevent the accumulation of fibrillar aggregates. Here, we integrated kinetic investigations with structural studies to elucidate how the ubiquitous co-chaperonin prefoldin inhibits diabetes associated islet amylo...

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Detalles Bibliográficos
Autores principales: Törner, Ricarda, Kupreichyk, Tatsiana, Gremer, Lothar, Debled, Elisa Colas, Fenel, Daphna, Schemmert, Sarah, Gans, Pierre, Willbold, Dieter, Schoehn, Guy, Hoyer, Wolfgang, Boisbouvier, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061850/
https://www.ncbi.nlm.nih.gov/pubmed/35501361
http://dx.doi.org/10.1038/s41467-022-30042-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061850/
https://www.ncbi.nlm.nih.gov/pubmed/35501361
http://dx.doi.org/10.1038/s41467-022-30042-y

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