A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Immunotherapy promotes the attack of cancer cells by the immune system; however, it is difficult to detect early responses before changes in tumor size occur. Here, we report the rational design of a fluorogenic peptide able to detect picomolar concentrations of active granzyme B as a biomarker of i...

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Detalles Bibliográficos
Autores principales: Scott, Jamie I., Mendive-Tapia, Lorena, Gordon, Doireann, Barth, Nicole D., Thompson, Emily J., Cheng, Zhiming, Taggart, David, Kitamura, Takanori, Bravo-Blas, Alberto, Roberts, Edward W., Juarez-Jimenez, Jordi, Michel, Julien, Piet, Berber, de Vries, I. Jolanda, Verdoes, Martijn, Dawson, John, Carragher, Neil O., Connor, Richard A. O’, Akram, Ahsan R., Frame, Margaret, Serrels, Alan, Vendrell, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061857/
https://www.ncbi.nlm.nih.gov/pubmed/35501326
http://dx.doi.org/10.1038/s41467-022-29691-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061857/
https://www.ncbi.nlm.nih.gov/pubmed/35501326
http://dx.doi.org/10.1038/s41467-022-29691-w

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