Novel cathepsin K inhibitors block osteoclasts in vitro and increase spinal bone density in zebrafish

Cathepsin K (Cat K) is a predominant cysteine protease and highly potent collagenase expressed in osteoclasts. Cat K inhibitors are anti-resorptive agents to treat osteoporosis. A novel scaffold of cathepsin K inhibitors, exemplified by lead compound 1x, was used as the template for designing and sy...

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Detalles Bibliográficos
Autores principales: Xue, Si-tu, Wang, Ya-li, Han, Xiao-wan, Yi, Hong, Jiang, Wei, Si, Shu-yi, Guo, Hui-fang, Li, Zhuo-rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061869/
https://www.ncbi.nlm.nih.gov/pubmed/35518710
http://dx.doi.org/10.1039/c8ra10338k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061869/
https://www.ncbi.nlm.nih.gov/pubmed/35518710
http://dx.doi.org/10.1039/c8ra10338k

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