The Okur-Chung Neurodevelopmental Syndrome Mutation CK2(K198R) Leads to a Rewiring of Kinase Specificity

Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of protein kinase CK2. The most frequently occurring mutation is lysine 198 to arginine (K198R). To investigate the impact of this mutation, we first generated a hi...

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Detalles Bibliográficos
Autores principales: Caefer, Danielle M., Phan, Nhat Q., Liddle, Jennifer C., Balsbaugh, Jeremy L., O’Shea, Joseph P., Tzingounis, Anastasios V., Schwartz, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062000/
https://www.ncbi.nlm.nih.gov/pubmed/35517865
http://dx.doi.org/10.3389/fmolb.2022.850661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062000/
https://www.ncbi.nlm.nih.gov/pubmed/35517865
http://dx.doi.org/10.3389/fmolb.2022.850661

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