Xylopins A–F, six rare guaiane dimers with three different connecting modes from Xylopia vielana

Six rare guaiane-type sesquiterpene dimers xylopins A–F, having three different connecting modes through two direct C–C bonds, were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOESY analysis, Cu Kα X-ray crystallography, and experimental and calculat...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Yang-Guo, Yan, Rong, Zhong, Xianglong, Piao, Huang, Muhammad, Ishaq, Ke, Xisong, Yan, Shikai, Guo, Yuanqiang, Jin, Hui-Zi, Zhang, Wei-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062023/
https://www.ncbi.nlm.nih.gov/pubmed/35517671
http://dx.doi.org/10.1039/c9ra00347a
Descripción
Sumario:Six rare guaiane-type sesquiterpene dimers xylopins A–F, having three different connecting modes through two direct C–C bonds, were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOESY analysis, Cu Kα X-ray crystallography, and experimental and calculated electronic circular dichroism spectra. Flow cytometry demonstrated the fact that compound 6 arrested the cell cycle at G2 phase and concentration-dependently induced apoptosis of DU145 cells. Furthermore, the EPT2-TGC cell model, zebrafish study and western blot analysis illustrated compound 6 could induce apoptosis by efficiently inhibiting the Wnt/β-catenin signaling pathway via decreasing the expression of β-catenin.