Diastereoselective approach to rationally design tetrahydro-β-carboline–isatin conjugates as potential SERMs against breast cancer

A series of tetrahydro-β-carboline–isatin conjugates, with varying substituents as well as stereochemistry at C-1 and C-5 position of tetrahydro-β-carboline (THβC) and isatin ring, were prepared and assayed for anti-proliferative efficacy on Estrogen Responsive ER(+) (MCF-7) and ER(−ve) MDA-MB-231 c...

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Detalles Bibliográficos
Autores principales: Sharma, Bharvi, Singh, Amandeep, Gu, Liang, Saha, Sourav Taru, Singh-Pillay, Ashona, Cele, Nosipho, Singh, Parvesh, Kaur, Mandeep, Kumar, Vipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062147/
https://www.ncbi.nlm.nih.gov/pubmed/35520746
http://dx.doi.org/10.1039/c9ra00744j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062147/
https://www.ncbi.nlm.nih.gov/pubmed/35520746
http://dx.doi.org/10.1039/c9ra00744j

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