Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation

Although several proteasome subunits have been shown to bind ubiquitin (Ub) chains, many ubiquitylated substrates also associate with 26S proteasomes via “shuttling factors.” Unlike the well-studied yeast shuttling factors Rad23 and Dsk2, vertebrate homologs Ddi2 and Ddi1 lack a Ub-associated domain...

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Detalles Bibliográficos
Autores principales: Collins, Galen Andrew, Sha, Zhe, Kuo, Chueh-Ling, Erbil, Beyza, Goldberg, Alfred L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062259/
https://www.ncbi.nlm.nih.gov/pubmed/35358511
http://dx.doi.org/10.1016/j.jbc.2022.101875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062259/
https://www.ncbi.nlm.nih.gov/pubmed/35358511
http://dx.doi.org/10.1016/j.jbc.2022.101875

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