A computational model of cardiomyocyte metabolism predicts unique reperfusion protocols capable of reducing cell damage during ischemia/reperfusion

If a coronary blood vessel is occluded and the neighboring cardiomyocytes deprived of oxygen, subsequent reperfusion of the ischemic tissue can lead to oxidative damage due to excessive generation of reactive oxygen species. Cardiomyocytes and their mitochondria are the main energy producers and con...

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Detalles Bibliográficos
Autores principales: Grass, Matthias, McDougal, Anthony D., Blazeski, Adriana, Kamm, Roger D., García-Cardeña, Guillermo, Dewey, C. Forbes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062261/
https://www.ncbi.nlm.nih.gov/pubmed/35157851
http://dx.doi.org/10.1016/j.jbc.2022.101693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062261/
https://www.ncbi.nlm.nih.gov/pubmed/35157851
http://dx.doi.org/10.1016/j.jbc.2022.101693

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