An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor

An efficient method for the synthesis of 3-functionalized quinolines from commercially available acetophenones and anthranil has been described. Selectfluor propels the C(sp(3))–H bond activation of the acetophenones and aza-Michael addition of anthranil resulting in annulated 3-acylquinolines in mo...

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Detalles Bibliográficos
Autores principales: Gao, Yejun, Hider, Robert C., Ma, Yongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062302/
https://www.ncbi.nlm.nih.gov/pubmed/35520934
http://dx.doi.org/10.1039/c9ra01481k
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author Gao, Yejun
Hider, Robert C.
Ma, Yongmin
author_facet Gao, Yejun
Hider, Robert C.
Ma, Yongmin
author_sort Gao, Yejun
collection PubMed
description An efficient method for the synthesis of 3-functionalized quinolines from commercially available acetophenones and anthranil has been described. Selectfluor propels the C(sp(3))–H bond activation of the acetophenones and aza-Michael addition of anthranil resulting in annulated 3-acylquinolines in moderate to high yields. DMSO acts not only as a solvent but also as a one carbon donor in the reaction.
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spelling pubmed-90623022022-05-04 An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor Gao, Yejun Hider, Robert C. Ma, Yongmin RSC Adv Chemistry An efficient method for the synthesis of 3-functionalized quinolines from commercially available acetophenones and anthranil has been described. Selectfluor propels the C(sp(3))–H bond activation of the acetophenones and aza-Michael addition of anthranil resulting in annulated 3-acylquinolines in moderate to high yields. DMSO acts not only as a solvent but also as a one carbon donor in the reaction. The Royal Society of Chemistry 2019-04-02 /pmc/articles/PMC9062302/ /pubmed/35520934 http://dx.doi.org/10.1039/c9ra01481k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Gao, Yejun
Hider, Robert C.
Ma, Yongmin
An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor
title An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor
title_full An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor
title_fullStr An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor
title_full_unstemmed An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor
title_short An efficient 3-acylquinoline synthesis from acetophenones and anthranil via C(sp(3))–H bond activation mediated by Selectfluor
title_sort efficient 3-acylquinoline synthesis from acetophenones and anthranil via c(sp(3))–h bond activation mediated by selectfluor
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062302/
https://www.ncbi.nlm.nih.gov/pubmed/35520934
http://dx.doi.org/10.1039/c9ra01481k
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