Reactive intermediates in naquotinib metabolism identified by liquid chromatography-tandem mass spectrometry: phase I metabolic profiling

Tyrosine kinase inhibitors (TKIs) are very efficient for the treatment of EGFR-mutated lung cancer and show improved therapeutic efficacy. However, treatment with both first- and second-generation TKIs results in acquired resistance and is related to various toxicities; the EGFR T790M mutation has b...

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Detalles Bibliográficos
Autores principales: Attwa, Mohamed W., Kadi, Adnan A., AlRabiah, Haitham, Darwish, Hany W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062305/
https://www.ncbi.nlm.nih.gov/pubmed/35520926
http://dx.doi.org/10.1039/c9ra00224c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062305/
https://www.ncbi.nlm.nih.gov/pubmed/35520926
http://dx.doi.org/10.1039/c9ra00224c

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