Computational normal mode analysis accurately replicates the activity and specificity profiles of CRISPR-Cas9 and high-fidelity variants

The CRISPR-Cas system has transformed the field of gene-editing and created opportunities for novel genome engineering therapeutics. The field has significantly progressed, and recently, CRISPR-Cas9 was utilized in clinical trials to target disease-causing mutations. Existing tools aim to predict th...

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Detalles Bibliográficos
Autores principales: Shor, Oded, Rabinowitz, Roy, Offen, Daniel, Benninger, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062324/
https://www.ncbi.nlm.nih.gov/pubmed/35521548
http://dx.doi.org/10.1016/j.csbj.2022.04.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062324/
https://www.ncbi.nlm.nih.gov/pubmed/35521548
http://dx.doi.org/10.1016/j.csbj.2022.04.026

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