Novel mono-lipidated dimeric glucagon-like peptide-1 receptor agonist with improved long-acting and hypoglycemic activity

Dimerization is a useful tool to boost ligand–receptor interaction. Both lipidation and dimerization effectively prolong the short half-life (t(1/2)) of peptides by facilitating binding with serum albumin and increasing hydrodynamic size. Here, we described two novel GLP-1 conjugates with high gluca...

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Detalles Bibliográficos
Autores principales: Sun, Lidan, Han, Jing, Chen, Xinyu, Han, Yue, Wu, Lingling, E, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062351/
https://www.ncbi.nlm.nih.gov/pubmed/35520704
http://dx.doi.org/10.1039/c9ra00833k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062351/
https://www.ncbi.nlm.nih.gov/pubmed/35520704
http://dx.doi.org/10.1039/c9ra00833k

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