Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial

IMPORTANCE: New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, developmental and epileptic encephalopathy. OBJECTIVE: To evaluate the efficacy and safety of fenfluramine in patients with LGS. DESIGN, SETTING, AND PARTICIPANT...

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Autores principales: Knupp, Kelly G., Scheffer, Ingrid E., Ceulemans, Berten, Sullivan, Joseph E., Nickels, Katherine C., Lagae, Lieven, Guerrini, Renzo, Zuberi, Sameer M., Nabbout, Rima, Riney, Kate, Shore, Svetlana, Agarwal, Anupam, Lock, Michael, Farfel, Gail M., Galer, Bradley S., Gammaitoni, Arnold R., Davis, Ronald, Gil-Nagel, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062770/
https://www.ncbi.nlm.nih.gov/pubmed/35499850
http://dx.doi.org/10.1001/jamaneurol.2022.0829