Higher Seroprevalence of Anti-Adeno-Associated Viral Vector Neutralizing Antibodies Among Racial Minorities in the United States

Anti-adeno-associated viral vector (AAV) neutralizing antibodies (NAbs) can ablate efficacy of transgene expression following intravenous vector administration. This observation in both preclinical and clinical trials has led to exclusion of NAb-positive patients from receiving AAV gene therapy. AAV...

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Detalles Bibliográficos
Autores principales: Khatri, Arpana, Shelke, Rajani, Guan, Shunjie, Somanathan, Suryanarayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063129/
https://www.ncbi.nlm.nih.gov/pubmed/34861783
http://dx.doi.org/10.1089/hum.2021.243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063129/
https://www.ncbi.nlm.nih.gov/pubmed/34861783
http://dx.doi.org/10.1089/hum.2021.243

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