Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

BACKGROUND: Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function and memory in mouse models, but Pyk2 deletion has minimal effect on neuro-i...

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Detalles Bibliográficos
Autores principales: Brody, A. Harrison, Nies, Sarah Helena, Guan, Fulin, Smith, Levi M., Mukherjee, Bandhan, Salazar, Santiago A., Lee, Suho, Lam, Tu Kiet T., Strittmatter, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063299/
https://www.ncbi.nlm.nih.gov/pubmed/35501917
http://dx.doi.org/10.1186/s13024-022-00526-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063299/
https://www.ncbi.nlm.nih.gov/pubmed/35501917
http://dx.doi.org/10.1186/s13024-022-00526-y

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