Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis

Asymmetric allylic substitution of Morita–Baylis–Hillman (MBH) carbonates with less-nucleophilic phenols mediated by nucleophilic amine catalysis was successfully developed. A variety of substituted aryl allyl ethers were afforded with moderate to high yields with excellent enantioselectivities. The...

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Autores principales: Zhao, Shuai, Jin, Lei, Chen, Zhi-Li, Rui, Xue, He, Jia-Yi, Xia, Ran, Chen, Ke, Chen, Xiang-Xiang, Yin, Zi-Jian, Chen, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063376/
https://www.ncbi.nlm.nih.gov/pubmed/35520223
http://dx.doi.org/10.1039/c9ra00155g
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author Zhao, Shuai
Jin, Lei
Chen, Zhi-Li
Rui, Xue
He, Jia-Yi
Xia, Ran
Chen, Ke
Chen, Xiang-Xiang
Yin, Zi-Jian
Chen, Xin
author_facet Zhao, Shuai
Jin, Lei
Chen, Zhi-Li
Rui, Xue
He, Jia-Yi
Xia, Ran
Chen, Ke
Chen, Xiang-Xiang
Yin, Zi-Jian
Chen, Xin
author_sort Zhao, Shuai
collection PubMed
description Asymmetric allylic substitution of Morita–Baylis–Hillman (MBH) carbonates with less-nucleophilic phenols mediated by nucleophilic amine catalysis was successfully developed. A variety of substituted aryl allyl ethers were afforded with moderate to high yields with excellent enantioselectivities. The chiral MBH alcohol could be easily accessed from the corresponding aryl allyl ether.
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spelling pubmed-90633762022-05-04 Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis Zhao, Shuai Jin, Lei Chen, Zhi-Li Rui, Xue He, Jia-Yi Xia, Ran Chen, Ke Chen, Xiang-Xiang Yin, Zi-Jian Chen, Xin RSC Adv Chemistry Asymmetric allylic substitution of Morita–Baylis–Hillman (MBH) carbonates with less-nucleophilic phenols mediated by nucleophilic amine catalysis was successfully developed. A variety of substituted aryl allyl ethers were afforded with moderate to high yields with excellent enantioselectivities. The chiral MBH alcohol could be easily accessed from the corresponding aryl allyl ether. The Royal Society of Chemistry 2019-04-12 /pmc/articles/PMC9063376/ /pubmed/35520223 http://dx.doi.org/10.1039/c9ra00155g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhao, Shuai
Jin, Lei
Chen, Zhi-Li
Rui, Xue
He, Jia-Yi
Xia, Ran
Chen, Ke
Chen, Xiang-Xiang
Yin, Zi-Jian
Chen, Xin
Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
title Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
title_full Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
title_fullStr Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
title_full_unstemmed Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
title_short Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
title_sort asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063376/
https://www.ncbi.nlm.nih.gov/pubmed/35520223
http://dx.doi.org/10.1039/c9ra00155g
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