Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

The 24‐h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate‐limiting step that determines the lifespan of a mRNA and is catalyzed by deadenylases. Herein, we determine the catalytic site of Hesperin...

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Detalles Bibliográficos
Autores principales: Beta, Rafailia A. A., Kyritsis, Athanasios, Douka, Veroniki, Papanastasi, Eirini, Rizouli, Marianna, Leonidas, Demetres D., Vlachakis, Dimitrios, Balatsos, Nikolaos A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063446/
https://www.ncbi.nlm.nih.gov/pubmed/33095977
http://dx.doi.org/10.1002/2211-5463.13011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063446/
https://www.ncbi.nlm.nih.gov/pubmed/33095977
http://dx.doi.org/10.1002/2211-5463.13011

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