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Importance of protein flexibility in ranking ERK2 Type I(1/2) inhibitor affinities: a computational study
Extracellular-regulated kinase (ERK2) has been regarded as an essential target for various cancers, especially melanoma. Recently, pyrrolidine piperidine derivatives were reported as Type I(1/2) inhibitors of ERK2, which occupy both the ATP binding pocket and the allosteric pocket. Due to the dynami...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063686/ https://www.ncbi.nlm.nih.gov/pubmed/35515820 http://dx.doi.org/10.1039/c9ra01657k |