Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding

Choline-O-sulfatase (COSe; EC 3.1.6.6) is a member of the alkaline phosphatase (AP) superfamily, and its natural function is to hydrolyze choline-O-sulfate into choline and sulfate. Despite its natural function, the major interest in this enzyme resides in the landmark catalytic/substrate promiscuit...

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Detalles Bibliográficos
Autores principales: Gavira, Jose Antonio, Cámara-Artigas, Ana, Neira, Jose Luis, Torres de Pinedo, Jesús M., Sánchez, Pilar, Ortega, Esperanza, Martinez-Rodríguez, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063841/
https://www.ncbi.nlm.nih.gov/pubmed/35503214
http://dx.doi.org/10.1107/S2059798322003709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063841/
https://www.ncbi.nlm.nih.gov/pubmed/35503214
http://dx.doi.org/10.1107/S2059798322003709

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