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Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding
Choline-O-sulfatase (COSe; EC 3.1.6.6) is a member of the alkaline phosphatase (AP) superfamily, and its natural function is to hydrolyze choline-O-sulfate into choline and sulfate. Despite its natural function, the major interest in this enzyme resides in the landmark catalytic/substrate promiscuit...
Autores principales: | Gavira, Jose Antonio, Cámara-Artigas, Ana, Neira, Jose Luis, Torres de Pinedo, Jesús M., Sánchez, Pilar, Ortega, Esperanza, Martinez-Rodríguez, Sergio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063841/ https://www.ncbi.nlm.nih.gov/pubmed/35503214 http://dx.doi.org/10.1107/S2059798322003709 |
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