Synthesis and antiproliferative assay of triazolyl-2,2-dimethyl-3-phenylpropanoates as potential HDAC inhibitors

Recently, histone deacetylase (HDAC) inhibition has gained great importance in cancer treatment. We herein, describe the design, synthesis and biological testing of 16 compounds based on the structure modification of methyl 3-(4-(2-chloroacetamido)phenyl)-3-hydroxy-2,2-dimethylpropanoate (5) and met...

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Detalles Bibliográficos
Autores principales: El-Rayes, Samir, M. S., Gomaa, A., Abouelmagd, Fathalla, Walid, Ali, Ibrahim. A. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064006/
https://www.ncbi.nlm.nih.gov/pubmed/35519591
http://dx.doi.org/10.1039/c9ra01277j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064006/
https://www.ncbi.nlm.nih.gov/pubmed/35519591
http://dx.doi.org/10.1039/c9ra01277j

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