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Using topic modeling to detect cellular crosstalk in scRNA-seq

Cell-cell interactions are vital for numerous biological processes including development, differentiation, and response to inflammation. Currently, most methods for studying interactions on scRNA-seq level are based on curated databases of ligands and receptors. While those methods are useful, they...

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Detalles Bibliográficos
Autores principales: Pancheva, Alexandrina, Wheadon, Helen, Rogers, Simon, Otto, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064087/
https://www.ncbi.nlm.nih.gov/pubmed/35395014
http://dx.doi.org/10.1371/journal.pcbi.1009975