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Detecting early stage structural changes in wild type, pathogenic and non-pathogenic prion variants using Markov state model
The conversion of prion protein from normal to scrapie followed by the aggregation and deposition of this scrapie form leads to various neurodegenerative diseases. A few studies carried out by researchers suggest that E219K prion mutant (glutamate to lysine mutation at residue position 219) is more...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064127/ https://www.ncbi.nlm.nih.gov/pubmed/35519320 http://dx.doi.org/10.1039/c9ra01507h |