One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source

A one-pot cyanation of 2,4-arylquinazoline with NIS and malononitrile has been developed. The one-pot reaction includes two steps. The Rh-catalyzed selective C–H activation/iodization of 2,4-diarylquinazoline with NIS, and then Cu-catalyzed cyanation of the corresponding iodinated intermediate with...

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Detalles Bibliográficos
Autores principales: Yan, Ziqiao, Ouyang, Banlai, Mao, Xunchun, Gao, Wei, Deng, Zhihong, Peng, Yiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064619/
https://www.ncbi.nlm.nih.gov/pubmed/35515228
http://dx.doi.org/10.1039/c9ra02979f
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author Yan, Ziqiao
Ouyang, Banlai
Mao, Xunchun
Gao, Wei
Deng, Zhihong
Peng, Yiyuan
author_facet Yan, Ziqiao
Ouyang, Banlai
Mao, Xunchun
Gao, Wei
Deng, Zhihong
Peng, Yiyuan
author_sort Yan, Ziqiao
collection PubMed
description A one-pot cyanation of 2,4-arylquinazoline with NIS and malononitrile has been developed. The one-pot reaction includes two steps. The Rh-catalyzed selective C–H activation/iodization of 2,4-diarylquinazoline with NIS, and then Cu-catalyzed cyanation of the corresponding iodinated intermediate with malononitrile to selectively give 2-(2-cyanoaryl)-4-arylquinazolines or 2-(2,6-dicyanoaryl)-4-arylquinazolines in good to excellent yields.
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spelling pubmed-90646192022-05-04 One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source Yan, Ziqiao Ouyang, Banlai Mao, Xunchun Gao, Wei Deng, Zhihong Peng, Yiyuan RSC Adv Chemistry A one-pot cyanation of 2,4-arylquinazoline with NIS and malononitrile has been developed. The one-pot reaction includes two steps. The Rh-catalyzed selective C–H activation/iodization of 2,4-diarylquinazoline with NIS, and then Cu-catalyzed cyanation of the corresponding iodinated intermediate with malononitrile to selectively give 2-(2-cyanoaryl)-4-arylquinazolines or 2-(2,6-dicyanoaryl)-4-arylquinazolines in good to excellent yields. The Royal Society of Chemistry 2019-06-11 /pmc/articles/PMC9064619/ /pubmed/35515228 http://dx.doi.org/10.1039/c9ra02979f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Yan, Ziqiao
Ouyang, Banlai
Mao, Xunchun
Gao, Wei
Deng, Zhihong
Peng, Yiyuan
One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source
title One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source
title_full One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source
title_fullStr One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source
title_full_unstemmed One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source
title_short One-pot regioselective C–H activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source
title_sort one-pot regioselective c–h activation iodination–cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064619/
https://www.ncbi.nlm.nih.gov/pubmed/35515228
http://dx.doi.org/10.1039/c9ra02979f
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