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Small DNA circles as bacterial topoisomerase I inhibitors

Bacterial topoisomerase I is a potential target during the course of antibacterial drug therapy. In our studies, specifically designed small DNA circles with high bending stress were synthesized. It is demonstrated that small DNA circles showed high inhibitory effect on the activity of bacterial top...

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Detalles Bibliográficos
Autores principales: Li, Dawei, Wang, Qiang, Zhou, Bing, Zhuge, Qiang, Lv, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064831/
https://www.ncbi.nlm.nih.gov/pubmed/35515216
http://dx.doi.org/10.1039/c9ra02398d