New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

ROR1, ROR2, and PTK7 are Wnt ligand-binding members of the receptor tyrosine kinase family. Despite their lack of catalytic activity, these receptors regulate skeletal, cardiorespiratory, and neurological development during embryonic and fetal stages. However, their overexpression in adult tissue is...

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Detalles Bibliográficos
Autores principales: Raivola, Juuli, Dini, Alice, Salokas, Kari, Karvonen, Hanna, Niininen, Wilhelmiina, Piki, Emilia, Varjosalo, Markku, Ungureanu, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064840/
https://www.ncbi.nlm.nih.gov/pubmed/35504983
http://dx.doi.org/10.1007/s00018-022-04301-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064840/
https://www.ncbi.nlm.nih.gov/pubmed/35504983
http://dx.doi.org/10.1007/s00018-022-04301-6

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