Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

PURPOSE: Gene fusions involving R-spondin (RSPOfp) and RNF43 mutations have been shown to drive Wnt-dependent tumor initiation in colorectal cancer. Herein, we aimed to characterize the molecular features of RSPOfp/RNF43 mutated (mut) compared with wild-type (WT) colorectal cancers to gain insights...

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Detalles Bibliográficos
Autores principales: Seeber, Andreas, Battaglin, Francesca, Zimmer, Kai, Kocher, Florian, Baca, Yasmine, Xiu, Joanne, Spizzo, Gilbert, Novotny-Diermayr, Veronica, Rieder, Dietmar, Puccini, Alberto, Swensen, Jeff, Ellis, Michelle, Goldberg, Richard M., Grothey, Axel, Shields, Anthony F., Marshall, John L., Weinberg, Benjamin A., Sackstein, Paul E., Lim, Kiat Hon, Tan, Gek San, Nabhan, Chadi, Korn, W. Michael, Amann, Arno, Trajanoski, Zlatko, Berger, Martin D., Lou, Emil, Wolf, Dominik, Lenz, Heinz-Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064897/
https://www.ncbi.nlm.nih.gov/pubmed/35254413
http://dx.doi.org/10.1158/1078-0432.CCR-21-3018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064897/
https://www.ncbi.nlm.nih.gov/pubmed/35254413
http://dx.doi.org/10.1158/1078-0432.CCR-21-3018

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