CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

The Hedgehog (HH) pathway is critical for development and adult tissue homeostasis. Aberrant HH signaling can lead to congenital malformations and diseases including cancer. Although cholesterol and several oxysterol lipids have been shown to play crucial roles in HH activation, the molecular mechan...

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Detalles Bibliográficos
Autores principales: Lo, Megan, Sharir, Amnon, Paul, Michael D., Torosyan, Hayarpi, Agnew, Christopher, Li, Amy, Neben, Cynthia, Marangoni, Pauline, Xu, Libin, Raleigh, David R., Jura, Natalia, Klein, Ophir D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065090/
https://www.ncbi.nlm.nih.gov/pubmed/35504891
http://dx.doi.org/10.1038/s41467-022-30186-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065090/
https://www.ncbi.nlm.nih.gov/pubmed/35504891
http://dx.doi.org/10.1038/s41467-022-30186-x

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