Multivalent interactions essential for lentiviral integrase function

A multimer of retroviral integrase (IN) synapses viral DNA ends within a stable intasome nucleoprotein complex for integration into a host cell genome. Reconstitution of the intasome from the maedi-visna virus (MVV), an ovine lentivirus, revealed a large assembly containing sixteen IN subunits(1). H...

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Detalles Bibliográficos
Autores principales: Ballandras-Colas, Allison, Chivukula, Vidya, Gruszka, Dominika T., Shan, Zelin, Singh, Parmit K., Pye, Valerie E., McLean, Rebecca K., Bedwell, Gregory J., Li, Wen, Nans, Andrea, Cook, Nicola J., Fadel, Hind J., Poeschla, Eric M., Griffiths, David J., Vargas, Javier, Taylor, Ian A., Lyumkis, Dmitry, Yardimci, Hasan, Engelman, Alan N., Cherepanov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065133/
https://www.ncbi.nlm.nih.gov/pubmed/35504909
http://dx.doi.org/10.1038/s41467-022-29928-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065133/
https://www.ncbi.nlm.nih.gov/pubmed/35504909
http://dx.doi.org/10.1038/s41467-022-29928-8

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