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High-throughput analysis of single human cells reveals the complex nature of DNA replication timing control

DNA replication initiates from replication origins firing throughout S phase. Debate remains about whether origins are a fixed set of loci, or a loose agglomeration of potential sites used stochastically in individual cells, and about how consistent their firing time is. We develop an approach to pr...

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Detalles Bibliográficos
Autores principales: Massey, Dashiell J., Koren, Amnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065153/
https://www.ncbi.nlm.nih.gov/pubmed/35504890
http://dx.doi.org/10.1038/s41467-022-30212-y