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The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP
Breast cancer type 1 susceptibility protein (BRCA1) is essential for homologous recombination repair of DNA double-strand breaks. Loss of BRCA1 is lethal to embryos due to extreme genomic instability and the activation of p53-dependent apoptosis. However, the apoptosis is resisted in BRCA1-deficient...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065249/ https://www.ncbi.nlm.nih.gov/pubmed/35517499 http://dx.doi.org/10.3389/fcell.2022.889656 |