Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via (1)H NMR, (13)C NMR, and HR MS. Preliminary antitumor activity as...

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Detalles Bibliográficos
Autores principales: Mao, Long-fei, Wang, Zhen-Zhen, Wu, Qiong, Chen, Xiaojie, Yang, Jian-Xue, Wang, Xin, Li, Yue-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065260/
https://www.ncbi.nlm.nih.gov/pubmed/35517789
http://dx.doi.org/10.3389/fphar.2022.849364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065260/
https://www.ncbi.nlm.nih.gov/pubmed/35517789
http://dx.doi.org/10.3389/fphar.2022.849364

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